Methylprednisolone therapy in a child with unresolving ARDS.
نویسندگان
چکیده
We report successful use of methyl-prednisolone in a 21-month old child with ARDS that did not improve with conventional therapy. The child improved and could be extubated after 10 days of methylprednisolone therapy. Subsequently, the child was weaned off supplementary oxygen. Methylprednisolone appeared to be safe and effective in a child with unresolving ARDS.
منابع مشابه
Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial.
CONTEXT No pharmacological therapeutic protocol has been found effective in modifying the clinical course of acute respiratory distress syndrome (ARDS) and mortality remains greater than 50%. OBJECTIVE To determine the effects of prolonged methylprednisolone therapy on lung function and mortality in patients with unresolving ARDS. DESIGN Randomized, double-blind, placebo-controlled trial. ...
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DOI: 10.1164/rccm.2106014 Internet address: www.atsjournals.org Nuclear factorB (NFB) and glucocorticoid receptor(GR) have diametrically opposed functions in regulating inflammation. We investigated whether unresolving acute respiratory distress syndrome (ARDS) is associated with systemic inflammationinduced glucocorticoid resistance and whether prolonged methylprednisolone administration accel...
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Context.—No pharmacological therapeutic protocol has been found effective in modifying the clinical course of acute respiratory distress syndrome (ARDS) and mortality remains greater than 50%. Objective.—To determine the effects of prolonged methylprednisolone therapy on lung function and mortality in patients with unresolving ARDS. Design.—Randomized, double-blind, placebo-controlled trial. Se...
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ورودعنوان ژورنال:
- Indian pediatrics
دوره 43 7 شماره
صفحات -
تاریخ انتشار 2006